| 產(chǎn)品編號 | IHC0617H |
| 英文名稱 | Human HLA-DPB1 Ready-To-Use IHC Kit |
| 中文名稱 | 人組織相容性復(fù)合體2即用型免疫組化試劑盒 |
| 別 名 | DPB1; HLA-DP; HLA-DP1B; HLA-DPB; HLA-DPB1; HLA-DPB; major histocompatibility complex; class II; DP beta 1 |
| 適用樣品基質(zhì) | FFPE tissue |
| 保存條件 | Please store components at the temperatures indicated on the individual tube labels. The kit is stable for 6 months from the date of receipt. |
| 產(chǎn)品介紹 |
HLA-DPB belongs to the HLA class II beta chain paralogues. This class II molecule is a heterodimer consisting of an alpha (DPA) and a beta chain (DPB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa and its gene contains 6 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DP molecule both the alpha chain and the beta chain contain the polymorphisms specifying the peptide binding specificities, resulting in up to 4 different molecules.
HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry. SWISS: P04440 Gene ID: 3115 |
| 產(chǎn)品圖片 |
Immunohistochemical analysis of paraffin embedded Human prostate cancer tissue slide using IHC0617H (Human HLA-DPB1 Kit).
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Immunohistochemical analysis of paraffin embedded Human colon cancer tissue slide using IHC0617H (Human HLA-DPB1 Kit).
Immunohistochemical analysis of paraffin embedded Human tonsil tissue slide using IHC0617H (Human HLA-DPB1 Kit).
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