| 產(chǎn)品編號(hào) | BIO0943SM |
| 英文名稱 | Anti-GPRC5D & CD3 Reference Antibody (Talquetamab Biosimilar) |
| 中文名稱 | |
| 別 名 | CD3 & GPRC5D; Talquetamab |
| 抗體來(lái)源 | |
| 克隆類型 | Monoclonal |
| 克 隆 號(hào) | |
| 交叉反應(yīng) | Human |
| 產(chǎn)品應(yīng)用 |
not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 理論分子量 | 144.98 kDa |
| 檢測(cè)分子量 | |
| 性 狀 | Lyophilized |
| 亞 型 | IgG-like |
| 純化方法 | Protein A |
| 緩 沖 液 | 100 mM Pro-Ac 20mM Arg pH 5.0 |
| 保存條件 | -80°C for 2 years under sterile conditions； -20°C for 1 year under sterile conditions；Avoid repeated freeze-thaw cycles. |
| 注意事項(xiàng) | This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | |
| 產(chǎn)品圖片 |
Plated and cultivated Talquetamab at 4℃ overnight, then with the addition of NF-AT-Jurkat cells for 6 hours. Bright-Lite was used to detect the fluorescent signal. As shown in fig, Talquetamab was able to activate the NF-AT signaling pathway, and the EC50 was 7.499 nM.
Talquetamab bound to huGPRC5D-HEK293 cells, and then rebounded to fluorescent secondary antibodies (Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig 3, Talquetamabbound to huGPRC5D-HEK293 cells, and the EC50 was 2.067 nM.
Talquetamab bound to huCD3e-jurkat cells, and then rebounded to fluorescent secondary antibodies (Anti-human IgG, Fcγ PE) , and test by flow cytometry. As shown in fig, Talquetamab bound to huCD3e-jurkat cells, and the EC50 was 6.175 nM.
Talquetamab bound to GPRC5D protein, and then rebounded to secondary antibodies (Anti-human-IgG-Fc-HRP) , and read OD450. As shown in fig, Talquetamab bound to hu-GPRC5D-VLP, and the EC50 was 0.978 nM.
The purity of Anti-GPRC5D & CD3 Reference Antibody (Talquetamab) is more than 97.10%, determined by SEC-HPLC.
Anti-GPRC5D & CD3 Reference Antibody (Talquetamab) on SDS-PAGE under reducing (R) condition. The purity of the protein is greater than 95%.
The detected molecular weight of Anti-GPRC5D & CD3 Reference Antibody (Talquetamab) is 144.32 kDa.
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